Beclin1 (Becn1) and Microtubule-associated proteins 1A/1B light chain 3B (LC3b) mRNA levels, protein level of BECN1 and the ratio of LC3B-II:I were increased at early-stage of AD but decreased at late-stage of AD mice as compared with WT (Figure 2A-H). This evidence concerns the gene BECN1 and Alzheimer disease.