In addition, Ramatroban significantly attenuated lung fibrosis, indicated by decreased collagen fiber content (Figure 7A), reduced fibrosis score (Figure 7A), decreased hydroxyproline level (Figure 7C), and down-regulated expression of fibronectin and collagen I at both the mRNA (Figure 7B) and protein levels (Figure 7D-E and Figure S14). Here, FN1 is linked to pulmonary fibrosis.