Inspired by the potential of the CCP/PCBP2 siRNA nanocomplex to improve the delivery of small-molecule drugs in the desmoplastic tumor microenvironment by reversing the accumulation of fibrotic stroma described above, in this study, we further tested the combinatorial effects of beneficial stroma modulation with chemotherapy in an orthotopic mouse model of stroma-rich pancreatic cancer, which was established by co-inoculating mice with PANC-1/Luc tumor cells mixed with NIH 3T3 fibroblasts (Figure 7A). This evidence concerns the gene PCBP2 and familial pancreatic carcinoma.