Interestingly, induced pluripotent stem cell-derived astrocytes from APOE4 AD patients that had been genetically converted with CRISPR-Cas9 to an APOE3 genotype showed a rescued overall phagocytic capacity, confirming the APOE allele-dependent phagocytic capacity of astrocytes in AD pathology 183. Here, APOE is linked to Alzheimer disease.