APP is the precursor protein for 1–40 β-amyloid protein, one of the two proteins (pTau being the other), that pathologically accumulates (in the form of extracellular 1–42 β-neuritic plaques) in subjects diagnosed with AD and it has been shown to interact with GAP43 in mechanisms of axonal generation and neuroplasticity as well56. The gene discussed is APP; the disease is Alzheimer disease.