MAPT and Alzheimer disease: Intriguingly, the observed phenomenon of decreased pTau levels induced by low-dose radiation contrasts with the opposite phenomenon observed in AD pathogenesis (and other tauopathies) where a progressive process of Tau hyperphosphorylation is instead associated with increased levels of insoluble pTau and its consequent accumulation in neurons and astroglial cells across the cerebral cortex 50,51.