APP is the precursor protein for 1–40 β-amyloid protein, one of the two proteins (pTau being the other), that pathologically accumulates (in the form of extracellular 1–42 β-neuritic plaques) in subjects diagnosed with AD and it has been shown to interact with GAP43 in mechanisms of axonal generation and neuroplasticity as well56. Here, GAP43 is linked to Alzheimer disease.