PIK3CA and neoplasm: We did find a tendency toward longer disease-free survival in cases with mutations in WNT, MAPK/ERK and PI3K pathways, however, in multivariate logistic regression analysis including the prognostic factors tumor stage and histological subtype, none of the four mutated pathways came out as an independent prognostic factor (Supplementary Fig. 2 and Supplementary Table 1).