The main KEGG signaling pathways related to the above mechanism are PI3K-Akt signaling pathway, MAPK signaling pathway, Apoptosis, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, Prostate cancer, Endocrine resistance, Relaxin signaling pathway, EGFR tyrosine kinase inhibitor resistance. Here, TNF is linked to Familial prostate cancer.