We have also identified positive association of the CpG island hypermethylated status of the ITGA1, ITGA9, NID1 and NID2 genes in tumors with their attribution to the hypermethylated epigenomic BC subtype determined for a subset of samples from the same collection by genome-wide bisulfite sequencing of the CpG islands by XmaI-RRBS. The gene discussed is NID1; the disease is breast cancer.