If under any circumstances the mechanisms of ITGA4 transcription in a tumor are activated (the activating mechanisms may be, for example, ectopic expression of a transcription factor, or activation of an otherwise inactive topologically associating domain), it would be more effective in the cells with nonmethylated ITGA4 promoter then in those with the hypermethylated one. Here, ITGA4 is linked to neoplasm.