Losses in 1q21 have been previously described in relation with EOCRC and gains in 8q24, a locus associated with CRC susceptibility polymorphisms which harbors MYC, an important proto-oncogene over-expressed in numerous tumors and related with the presence of synchronous adenomas elsewhere in the colon24,32–34. The gene discussed is MYC; the disease is colorectal carcinoma.