CHEK2 and neoplasm: Finally, our western blotting analysis also corroborated substantial activation of p-Chk2 (Thr68) (3.54-fold) and p53 (5.82-fold) concurrent with downmodulation of p-Vimentin (ser38) (18.2-fold) and Vimentin (8.3-fold) in tumor tissues from 4DPG-treated group of animals compared to the saline treatment group (Fig. 4I, J).