Moreover, STAT3 mutations cause a rare human immunodeficiency disease, Job’s syndrome, featuring reduced BMD, recurrent fractures, and scoliosis.76 These published data are consistent with the phenotypes observed in SHP2KOBglap mice, such as a porous skeleton and reduced BMD, and indicate that signaling along the SHP2/STAT3 axis in OBs is critical for osteoclastogenesis and the maintenance of bone mineral homeostasis. This evidence concerns the gene STAT3 and scoliosis.