Additionally, on the basis of the fact that NRG1 stimulated cardiomyocyte proliferation in young adult mice,145,147,148 studies have found that NRG1 can also induce cardiomyocyte proliferation in infants under 6 months of age with heart disease.149 It suggests that NRG1 signal pathway is conservative and may serve as an effective therapeutic strategy for children with heart diseases. This evidence concerns the gene NRG1 and heart disorder.