Recently, ZIKV infection has been shown to delay apoptosis at early stages of infection to ensure the effective production of virions by regulating Bcl242, this could be attributed to the reason that we could see only subtle changes in the Bcl2 levels after 8–24 h of infection, a time point where we observed changes in ER stress markers. The gene discussed is BCL2; the disease is Zika virus infectious disease.