These oral symptoms like dry mouth, amblygeustia, dryness, and inflammation of the mouth and submandibular lymph nodes enlargement can be attributed to high ACE2 in tongue epithelial cells, providing a possible entry route to SARS-CoV-2, besides being present in salivary glands.31 Thus oral symptoms and hygiene can attain a crucial role in diagnosing and preventing COVID-19 and requires further exploration. The gene discussed is ACE2; the disease is xerostomia.