LRP1 and Hypercholesterolemia: In view of studies showing a direct link between HFHC diet, hypercholesterolemia, and β-amyloid accumulation in mice (31), the improved brain phenotype observed in HFHC diet-fed LRP1 mutant mice compared with wild-type mice may also be related to the elevated rate of plasma lipoprotein clearance and the suppression of diet-induced hypercholesterolemia observed in these animals.