LRP1 and obesity due to melanocortin 4 receptor deficiency: The inactivation of LRP1 in mature white and brown adipocytes reduces diet-induced obesity and insulin resistance by redistributing lipid nutrients to the muscle to support thermogenesis (16), but the lack of LRP1 in mature adipocytes also increases inflammation and accelerates atherosclerosis in hyperlipidemic mice with normal LRP1 expression in the vessel wall (17).