The reduced number of macrophages in the adipose tissues of HFHC diet-fed mutant mice was also evident by lower expression levels of EMR1 (F4/80), MCP1/CCL2, and MIP1α/CCL3 than that observed in wild-type mice, or in wild-type and mutant mice fed the HF diet (Fig. 1H). Here, CCL2 is linked to hydrops fetalis.