These results are different than those observed in adipocyte-specific LRP1 knockout mice, which showed improved glucose tolerance and insulin sensitivity due to compensatory nutrient utilization for muscular thermogenesis (16), or liver-specific LRP1 knockout mice that showed exaggerated diet-induced hyperglycemia and hyperinsulinemia due to hepatic insulin resistance (11). The gene discussed is LRP1; the disease is Hyperinsulinemia.