In addition, hepatic LRP1 deficiency synergizes with dietary cholesterol to exaggerate HF diet-induced liver diseases by accelerating hepatosteatosis progression to steatohepatitis (13), whereas distal NPxY mutation in LRP1 was found to limit obesity, prevent dyslipidemia, and suppress fatty liver disease progression in response to HFHC diet. Here, LRP1 is linked to metabolic syndrome.