The mechanism by which mutation of the distal NPxY motif in LRP1 reduces PCSK9 expression to alleviate dietary cholesterol-induced hypercholesterolemia and steatohepatitis was investigated by comparing the expression of lipid metabolism genes in the liver of wild-type and LRP1 NPxY mutant mice under various dietary conditions. The gene discussed is LRP1; the disease is familial hypercholesterolemia.