Despite the reduced adiposity and adipose tissue inflammation, as well as higher insulin sensitivity in the adipose tissues of LRP1 NPxY mutant mice fed the HFHC diet, both wild-type and mutant mice showed similarly high fasting glucose and insulin levels, leading to a similar insulin resistance index regardless of the cholesterol content in the HF diet (Fig. 2A–C). This evidence concerns the gene LRP1 and hydrops fetalis.