LRP1 and atherosclerosis: Previous studies have shown that mutation in the LRP1 distal NPxY motif does not affect ligand binding or its regulation of cell signaling events but compromises the rate of LRP1 endocytosis and recycling that leads to delayed postprandial lipid clearance, accelerated atherosclerosis, and increased inflammatory response in Ldlr−/− mice (33, 34).