Results showed that HF diet, both with or without additional cholesterol supplementation, reduced expression of SREBP2 and SREBP2-sensitive genes such as HMG CoA synthase (HMGCS) and HMG CoA reductase (HMGCR) in addition to the reduction of the LDL receptor (LDLR). The gene discussed is HMGCS1; the disease is hydrops fetalis.