As a result, expression levels of inflammatory cytokines such as TNFα and IL-1β were also found to be elevated in both wild-type and mutant mice under HF feeding conditions, and the expression levels of these cytokines were further enhanced in wild-type mice but reduced in the LRP1 mutant mice when fed the HFHC diet (Fig. 5C). The gene discussed is TNF; the disease is hydrops fetalis.