The lack of apparent effect of CETP on the time course of plasma LPS levels in our sepsis model might relate to the peculiar kinetic behavior of LPS, which is progressively and constantly delivered into the circulation over at least 24 h after CLP (11, 37, 38, present study), contrarily to our endotoxemia model, which consists of an unique LPS bolus. Here, CETP is linked to Sepsis.