In parallel, the contribution of CETP to resistance against sepsis and its harmful consequences was investigated by comparing wild-type (WT) and heterozygous human CETP-expressing (CETPTg) mice in two models of acute inflammation, i.e., after intravenous (iv) injection with purified LPS or induction of polymicrobial infection as obtained after cecal ligation and puncture (CLP). The gene discussed is CETP; the disease is Sepsis.