There have been no reports concerning the relationship between ficolin-3 and RF but several findings are indicating that high levels of ficolin-3 may contribute to the induction of inflammation as in diabetic retinopathy [28], leprosy [29], ovarian cancer [30], acute leukemia [31] and associated with post-operative graft loss in kidney transplantation [32]. Here, FCN3 is linked to diabetic retinopathy.