EMT was induced by hypoxia in a variety of tumors including non-small cell lung cancer (NSCLC) and ovarian carcinoma [36, 37], and the mechanism involves the regulation of SNAIL, twist family bHLH transcription factor (TWIST) and snail family transcriptional repressor 2 (SLUG) [38, 39]. Here, TWIST1 is linked to non-small cell lung carcinoma.