The comparison of CTRP5, CTRP1, adiponectin circulating levels, and ratio of CTRP1 to CTRP 5 between T2D patients and controls (Fig. 1) revealed that CTRP-1 and CTRP1/CTRP5 ratio were significantly higher in patients with T2D rather than in controls (P < 0001 and P = 0004 respectively). This evidence concerns the gene C1QTNF1 and type 2 diabetes mellitus.