Mounting evidence points to the role of CTRP 5 in regulating energy metabolism, insulin signaling, inflammatory pathways, migration, and proliferation in vascular smooth muscle cells which all are involved in the pathomechanism of T2D and CVDs.In detail, CTRP5 increases glucose uptake via stimulating incorporation of the glucose transporter 4 (GLUT4) into the plasma membrane by a mechanism dependent on AMPK phosphorylation. The gene discussed is INS; the disease is type 2 diabetes mellitus.