To reach this purpose, we investigated to address the association of circulating CTRP1 and CTRP5 with carotid intima-media thickness (cIMT) as well as various obesity indices including body mass index (BMI), waist, hip, waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and visceral adiposity index (VAI) in patients with T2D. This evidence concerns the gene C1QTNF1 and obesity due to melanocortin 4 receptor deficiency.