Finally, the mutated form of E7 protein that contained substantial substitution at positions C24G, L67R, and C91G (E7GRG) was considered as an appropriate candidate vaccine antigen, and upon formulation with 2′3′-cGAMP STING activator and CpG-C (ODN-2395) adjuvants, induced a potent immune response and inhibited tumor growth in mouse model. This evidence concerns the gene STING1 and neoplasm.