Rapamycin-sensitive mTORC1 promote HCC growth and progression via directly targeting phosphorylation and activation of ribosomal protein S6 kinase (p70S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (eIF4EBP1) [37]. The gene discussed is EIF4EBP1; the disease is hepatocellular carcinoma.