Silencing LINC01116 and TPM1 were achieved in CRC cells to measure cell proliferation and angiogenesis and the detection revealed that inhibition of LINC01116 and TPM1 in CRC cells can further enhance cell proliferation and angiogenesis than LINC01116 knockdown alone, suggesting that TPM1 may be regulated by LINC01116 in CRC cells. This evidence concerns the gene TPM1 and colorectal carcinoma.