By generating lncRNA-miRNA-mRNA interaction networks and performing univariate survival analysis of the genes coexpressed with lncRNAs in HCC, we demonstrated that SNHG1 has the same effect on patient survival as E2F8, FANCE and LMNB2. Single-cell analysis also demonstrated that E2F8 may play an important role in tumorigenesis or cancer development. This evidence concerns the gene LMNB2 and hepatocellular carcinoma.