In the ceRNA network established in this study, we found SNHG1-hsa-miR-421-E2F8, SNHG1-hsa-miR-377-3p-E2F8, SNHG1-hsa-miR-330-5p-LMNB2, and SNHG1-hsa-miR-326-FANCE axes in HCC. This evidence concerns the gene SNHG1 and hepatocellular carcinoma.