The aim of this study was to investigate the expression of plasma S100A8/A9 in IgE-mediated food allergies and its correlation with immune- and inflammatory-related factors, such as TLR4, nuclear transcription factors (NF-κB) and tumor necrosis factor α (TNF-α), terleukin-6 (IL-6) and IL-1β, to provide more experimental data regarding the mechanisms underlying food allergies. This evidence concerns the gene IL6 and food allergy.