Whilst these confirmed overlap between the mouse and human populations, such as an upregulation of the APOE gene [105], they also revealed changes to other AD-linked genes not seen in the animal models (e.g. the complement component gene, C1QB, and the pattern recognition receptor, CD14), and no change to those tied to DAM progression in mice (e.g. TREM2). Here, APOE is linked to Alzheimer disease.