PSMA1 and neoplasm: Doses for PSMA-1-VcMMAE of 382 nmol/kg, MMAE of 700 nmol/kg, and PSMA-ADC of 50 nmol/kg were the lowest effective drug concentrations to inhibit tumor growth for 30 days; therefore, the therapeutic indexes, which were defined as the ratio of the minimal effective dose that can inhibit tumor growth to its maximum tolerated dose, of PSMA-1-VcMMAE, MMAE, and PSMA-ADC were 20, 1, and 12.8, respectively (Figure S7, Table S1).