It was also found that PSMA-1-VcMMAE was significantly more effective at inhibiting PSMA-positive PC3pip tumor growth than PSMA-negative PC3flu tumor growth when used at the dose of 955 nmol/kg (p = 0.0493) (Figure S8), indicating selective killing of PSMA-1-VcMMAE by targeting PSMA. The gene discussed is PSMA1; the disease is neoplasm.