We found that the levels of phosphorylated 70 kDa ribosomal S6 kinase (p70S6K), the direct downstream effector of mTORC1, and the levels of phosphorylated S6 ribosomal protein (pS6Rb), a p70S6K substrate, decreased gradually in LN18 glioma cells after the exposure to cannabinoids (Figure 6e,f). Here, RPS6 is linked to central nervous system cancer.