Actually, many studies have suggested that the factors relating to the tumor microenvironment (TME), such as PD-L1 expression or the presence of tumor-infiltrating lymphocytes (TIL), could be prognostic or predictive marker candidates for chemotherapy or chemoradiation in various types of human cancers, including ESCC [18,19,20,21,22,23]. The gene discussed is CD274; the disease is esophageal squamous cell carcinoma.