IL1B and arthritic joint disease: As such, resveratrol appears to hold great potential for clinical translation as a novel therapy for RA, as showed by an in vivo study with bovine type-II collagen (BIIC)-induced Sprague–Dawley rat arthritis model and an in vitro arthritis model based on interleukin (IL)-1β-stimulated rat synovial cells (RSC-364) [153].