Elevated levels of inflammation markers and mediators and acute phase reagents such as fibrinogen, C-reactive protein (CRP), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), sialic acid, and leukocyte count correlate up with the incidence of T2D [67,68,69,70,71,72]. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.