Resveratrol alleviated arthritis through the activation of Nrf2-ARE (antioxidant response elements) signaling pathway via SIRT1/NF-κB/miR-29a-3p/Keap1 and SIRT1/NF-κB/miR-23a-3p/cul3 signaling pathway [154]. The gene discussed is KEAP1; the disease is arthritic joint disease.