Recent observations indicate that CRBN can be targeted and degraded by SCFFbxo7 E3 ubiquitin ligase [44], and sequential treatment with proteasome inhibitors followed by IMiDs can maintain high levels of CRBN in MM cells thus potentiating Ikaros/Aiolos degradation and cell death [45]. The gene discussed is IKZF3; the disease is Miyoshi myopathy.