Importantly, depletion of Ikaros and Aiolos leads to the downregulation of c-Myc and Interferon regulatory factor 4 (IRF4), two known critical TFs/ oncogenes sustaining MM growth and survival [28], and this represents one of the most important mechanisms of the antiproliferative and pro-apoptotic activity mediated by IMiDs in these cells. This evidence concerns the gene IKZF3 and Miyoshi myopathy.