IKZF3 and Miyoshi myopathy: Moreover, among ISGs, Ikaros and Aiolos repress CD38 expression through interaction with the nucleosome remodeling and deacetylase complex, and IMiD-induced degradation of these TFs can upregulate CD38 cell surface expression in MM cells, priming them for Daratumumab-induced NK cell-mediated antibody-dependent cellular cytotoxicity (ATCC) [38].