IRF4 and Miyoshi myopathy: Indeed, as for IRF4, depletion of either KLF2 or KDMA3 triggers apoptosis and reduces the adhesion of MM cells to BM stromal cells, which is critical for sustaining their growth and survival; more intriguingly, the loss of each protein impairs MM cell migratory ability and homing to BM by reducing the expression of the adhesion molecule Integrin alpha-4/beta-7 (ITGB7) [35].