The remaining eight haplotypes captured 85percent of genetic variance of women having normal bone mass and 88 percent of women having osteoporosis (Table 7).The major alleles at position 1, 2, 5 and 6 and minor alleles at 3 and 4 of studied eNOS SNPs appeared in the form of haplotype TGAAGT was having highest frequency, hence served as referent for the analysis. Here, NOS3 is linked to osteoporosis.