ACE and osteoporosis: Nevertheless in order to see the participation and contribution of other pertinent genes (ACE and VEGFA), results exhibited that two susceptibility haplotypes ACDG (in the order of rs4459609, rs1800764, rs1799752 and rs4343) and GATA (in the order of rs2010963, rs699947, rs833061 and rs1570360) exist within ACE and VEGFA gene and each unit of these haplotypes increases the osteoporosis risk by 1.73 ± 0.54 and 3.07 ± 0.81 (β ± SE) times respectively, which is manifested in dominant mode.