SNP rs4459609 polymorphism of ACE gene failed to show any association with osteoporosis risk (Table 4) whereas, minor allele C of rs1800764 showed association in codominant homozygous (OR 1.71, 95%CI: 1.08–3.17, p = 0.038), and multiplicative modes (OR 1.22, 95%CI: 1.01–1.62, p = 0.043). This evidence concerns the gene ACE and osteoporosis.