Furthermore, it has been confirmed by AUROC analysis in this study that the predictive power of individual TRD is not robust but when its effect is attached to that of susceptibility haplotype within VEGFA gene (GATA), it can predict osteoporosis with substantial power (AUC = 0.8 ± 0.022, p < 0.001), which is further supplemented, if, susceptibility haplotype within eNOS gene (CTAAAT) is also included in the analysis (AUC = 0.824 ± 0.020, p < 0.001). The gene discussed is NOS3; the disease is osteoporosis.