MAPT and Alzheimer disease: Key evidence in favour of the tau hypothesis include: (a) Strongly correlated distribution of tau pathology with the extent of cognitive and clinical symptoms, (b) tau lesions precede Aβ accumulation in the brain, (c) tau spatial patterns are closely correlated to neurodegeneration patterns [67], and (d) no correlation between amyloid plaques and loss of synapses and neurons in brains of AD patients [66].