The advantages of AD transgenic rat models over mouse models are: (1) Closer physiological, morphological and genetic characteristics to human; (2) larger brain volume, facilitating imaging, sample collection and electrophysiology studies; (3) formation of NFTs with endogenous rat tau (TgF344-AD rats); (4) the consistent development of AD associated cognitive impairment [23]. This evidence concerns the gene MAPT and Alzheimer disease.