MAPT and Alzheimer disease: Therefore, current treatment developing strategies are underpinned by efforts to manage AD′s multifactorial pathogenesis, to mitigate simultaneously the parallel pathological processes of neuroinflammation (with increased release of cytotoxic hydrogen peroxide), oxidative stress, mitochondrial dysfunction, disparity of zinc and copper ions, and formation of soluble toxic AβOs and tau hyperphosphorylation [60,76,77,78,79,80,81,82,83,84].