AKT1 and breast carcinoma: Furthermore, Bai and colleagues [7] reported that TCD significantly suppressed human MCF-7 breast cancer cell proliferation and induced cell apoptosis through the modulation of cell signaling cascades, such as protein kinase B (PKB or Akt)/nuclear factor-kappa B (NF-κB), p38 mitogen-activated protein kinases (MAPK), and p53 phosphorylation.