A MALT lymphoma with extensive plasmacytic differentiation, occasionally featuring intranuclear inclusions (Dutcher bodies) and cytoplasmic crystalline structures (Snapper-Schneider inclusions), may resemble a plasmacytoma; the presence of diffuse sheets of plasmacytoid lymphocytes rather than being located beneath epithelia, their positivity for cyclin D1 and CD56 and negativity for CD20, as well as the absence of monocytoid and centrocyte-like lymphocytes, and lymphoepithelial lesions, all favor the diagnosis of a plasma cell neoplasm over MALT lymphoma [4,52]. This evidence concerns the gene CCND1 and MALT lymphoma.