CD8A and cancer: Since Poly6 was subcutaneously injected into a region distant from the site of cancer cell inoculation, and it led to apoptotic cancer cell death primarily due to CD8 T cell-mediated CTL response in the tumor microenvironment, we hypothesized that Poly6 treatment would lead to the recruitment of activated innate APCs, including macrophages or DCs, into the tumor microenvironment, resulting in activation of the cancer-specific CD8 T cell-mediated CTL response.