Importantly, and consistent with all our previous studies [41,42,43], the cytotoxic activities of affinity optimized CD38-CAR iNKTs were also exclusively directed against CD38highCD138+ MM cells, while CD38int/high CD138- non-malignant cells were largely ignored, as shown in Figure 3A. Of note, in seven out of the eight samples there was little or no CD1d+ expression MM cells. This evidence concerns the gene CD38 and Miyoshi myopathy.