Therefore, Rhim et al. generated a transgenic mouse model called ShhPKCY (Shhflox/flox; p53fl/+; KrasLSL-G12D/+; Pdx1-Cre; Rosa26LSL-YFP) to perform targeted depletion of Shh in the pancreas and to visualize epithelial cells during tumor progression via YFP expression [66,67]. This evidence concerns the gene SHH and neoplasm.