Despite lower MHC I presentation, cancer cells are resistant to NK cell mediated lysis, which can be caused by multiple mechanisms, including: (1) increasing expression of NK cell inhibitory ligands, (2) secreting tumor growth factor β (TGFβ) to prevent NK cell activation, (3) secreting soluble NK cell ligands into the ECM to prevent NK cell contact with the tumor cell, a process that may be mediated by metalloproteinases (MMPs) from both cancer cells and CAFs [36,37,38,39]; or (4) interact with other cellular components of the TME, like CAFs [12,36]. This evidence concerns the gene TGFB1 and neoplasm.