For example, in renal clear cell carcinomas, which are characterized by aberrant lipid and glycogen accumulation, it was found that hypoxia-inducible factor 2 alpha (HIF2-α) can drive the production of PUFAs, through the activity of hypoxia-inducible, lipid droplet-associated protein (HILPDA) [91]. This evidence concerns the gene EPAS1 and clear cell renal carcinoma.