Within the 8q24.21 loci, a common site of translocation is within PVT1. PVT1 was initially identified as a site for variant translocation involving the Ig kappa locus and PVT1 gene in murine plasmocytomas [166], with the equivalent translocation observed in Burkitt’s lymphoma in human [167]. This evidence concerns the gene PVT1 and Burkitt lymphoma.