Moreover, administration of α7 nAChR selective agonist 3-[(2,4-dimethoxy) benzylidene]-anabaseine dihydrochloride (DMXBA) attenuated brain Aβ burden and memory dysfunction in a mouse model of AD [131] as well as dopaminergic neurodegeneration and glial activation in a rat model of Parkinson disease [132]. This evidence concerns the gene CHRNA7 and Alzheimer disease.