Elevations in plasma CgA are principally associated with neuroendocrine tumor disease; increased levels may also occur in nongastrointestinal cancers, endocrine disease (such as pheochromocytoma or hyperthyroidism), gastrointestinal disorders, renal insufficiency, chronic inflammatory, and cardiovascular diseases [14]. This evidence concerns the gene CGA and hereditary pheochromocytoma-paraganglioma.