In the MDA-MB-231 MV proteome, 23 Wnt signaling pathway proteins were identified based on their GO biological process, five of which—Rho associated coiled-coil containing protein kinase 2 (ROCK2), casein kinase 2 alpha 1 (CSNK2A1), casein, kinase 2 alpha 2 (CSNK2A2), catenin beta 1 (CTNNB1), and glycogen synthase kinase 3 beta (GSK3B)—have a known cancer association. This evidence concerns the gene CSNK2A1 and cancer.