TNF and obesity due to melanocortin 4 receptor deficiency: Even more interestingly, consistent results have been shown for resistin, which seems to play a key role in the pathogenesis of the disease through an increase in secretion of pro-inflammatory cytokines such as IL-6, IL-12 and TNF-α via activation of nuclear factor-B signal pathway and is also increased in obesity and other chronic inflammatory states [148,149,150].