TNF and type 2 diabetes mellitus: The consumption of EPA (180 mg/d) and DHA (120 mg/d) for six weeks was associated with a reduction in CRP in overweight patients [34], and a similar anti-inflammatory pattern was observed in a study with patients with T2DM, where the supplementation of high doses of n-3 PUFAs led to lower concentrations of IL-2 and TNF-α [35].