HMOX1 and systemic lupus erythematosus: These results agree with Castejon et al., showed that both dietary OL and Per-OL treatments induced an activation of Nrf2/HO pathway and prevented the MAPK activation and nuclear NF-κB-p65 and NF-κB-p50 translocations by blocking IκB-α degradation in a pristane-induced SLE murine model.