Park and colleagues recently showed that exosomes- derived from different tumor cell lines cultured in hypoxic conditions- were highly enriched in multiple immunomodulatory factors including TGF-β and let-7a miRNA; these exosomes were effective in promoting infiltrating myeloid cell polarization toward the M2-macrophage phenotype and boosting their activation effector functions by enhancing OXPHOS through the reduction of AKT and mTOR phosphorylation [163]. The gene discussed is TGFB1; the disease is neoplasm.