Although only one copy of the SLC25A1 gene is lost in 22q11.2 deletion syndrome, together with 30–40 other genes, a reduction in CIC levels in zebrafish (Danio Rerio) leads to abnormal morphant development in a dose-dependent manner, thus suggesting that reduced SLC25A1 allele dosage is indeed pathogenic [15,61,62]. The gene discussed is SLC25A1; the disease is 22q11.2 deletion syndrome.