However, while wild-type p53 suppresses transcription, tumor-associated mutant(s) forms of p53 do not bind to the promoter directly but are recruited therein through interaction with the transcription factor Forkhead Box O1 (FOXO1), which has very important activities in the regulation of insulin signaling, gluconeogenesis and glycogenolysis. The gene discussed is FOXO1; the disease is neoplasm.