TLR4 and cardiovascular disorder: This association is supported by the finding that elevated Fet A serum levels indicate increased liver fat [14], which in turn has also been shown to be associated with increased cardiovascular disease [45]; (ii) the ability of Fet A together with saturated fatty acids e.g., palmitate to stimulate a pro-inflammatory cascade via activating toll-like receptor 4, thus promoting endothelial dysfunction and vascular disease [15,28].