VEGFA and cancer: This characteristic of the zebrafish model is particularly useful for studying cancer therapy associated cardiotoxicity; several classes of targeted therapies, including VEGF pathway inhibitors, Bcr/Abl kinase inhibitors, and histone deacetylase inhibitors, have been documented to cause prolongation of ventricular depolarization, as measured by the corrected QT interval (QTc), in patients with cancer [18].