Typically, HER3, one member of EGFR family (EGFR, HER2, HER3, and HER4), plays a significant role in the formation of a heterodimer with EGFR on the surface of CRC cells, activating the intracellular signaling pathway when a ligand binds to the receptor [14,15]. Here, EGFR is linked to colorectal carcinoma.