In addition, we found a positive correlation between pretreatment sPD-1 levels and quantities of tumor infiltrating PD-1+ T cells (ρ = 0.396, p = 0.012, n = 39; Figure 3B), PD-1+ T-helper cells (ρ = 0.433, p = 0.019, n = 29), PD-1+ cytotoxic T cells (ρ = 0.385, p = 0.039, n = 29), and PD-L1+ tumor-associated macrophages (TAMs) (ρ = 0.397, p = 0.012, n = 39). Here, CD274 is linked to neoplasm.